Physiological parameters as a key tool for understanding and optimizing yeast metabolism and physiology in batch cultures

Abstract

Yeasts, as versatile microorganisms, play a vital role in numerous biotechnological applications, including biofuel production, food and beverage fermentation, and pharmaceutical manufacturing. To harness their full potential, it is crucial to understand the kinetics of yeast metabolism and physiology. This review highlights the importance of physiological parameters in assessing yeast behavior under different batch culture conditions. Key parameters such as maximum specific growth rate (μmax), specific substrate consumption rate (μS), yields (YX/S and YP/S), and productivities (PX and PP) provide valuable insights into yeast utilization and production of organic compounds. By compiling data on physiological parameters for different yeast strains grown under diverse conditions, researchers can identify optimal genetic modifications, pathway constructions, strain selections, substrate choices, and culture conditions. This knowledge enables the bridging of the gap between laboratory-scale experiments and industrial applications, facilitating the development of efficient and sustainable bioprocesses. Physiological parameters serve as a practical tool for optimizing yeast-based biotechnological processes.