Modeling and simulating study on disorder of associative memory function of hippocampal CA3 region caused by synaptic deletion based on Hopfield-like spiking neural network model

Abstract

Objective A spiking Hopfield-like neural network was proposed and used to simulate the disorder of hippocampal associative memory disorder caused by synaptic deletion.Methods A three-layered Hopfield-like spiking neural network model with auto-associative memory function and hetero-associative memory function was proposed according to anatomical structure of hippocampal CA3,and both associative memories of the models were simulated under Matlab platform.Disorder of hippocampal associative memory was also simulated according to Ruppin's 'synaptic deletion' theory.Results With the increasing of synaptic deletion level,both associative memory functions impaired gradually.Conclusion Synaptic deletion of hippocampal CA3 region can lead to the disorder of autoassociative memory as well as heteroassociative memory. Key words: Hippocampal CA3; Synaptic deletion; Hopfield-like neural network; Autoassociative memory; Heteroassociative memory