Abstract
While artemisinin is known as anticancer medication with favorable remedial effects, its side effects must not be neglected. In order to reduce such side effects and increase artemisinin therapeutic index, nano technology has been considered as a new approach. Liposome preparation is supposed to be one of the new methods of drug delivery. To prepare the desired nanoliposome, certain proportions of phosphatidylcholine, cholesterol and artemisinin are mixed together. Besides, in order to achieve more stability, the formulation was pegylated by polyethylene glycol 2000 (PEG 2000). Mean diameter of nanoliposomes was determined by means of Zeta sizer. Encapsulation was calculated 96.02% in nanoliposomal and 91.62% in pegylated formulation. Compared to pegylated formulation, the percent of released drug in nanoliposomal formulation was more. In addition, this study reveals that cytotoxicity effect of pegylated nanoliposomal artemisinin was more than nanoliposomal artemisinin. Since artificial neural network shows high possibility of nonlinear modulation, it is used to predict cytotoxicity effect in this study, which can precisely indicate the cytotoxicity and IC50 of anticancer drugs.
Highlights
While cancer is known to be one of the widespread diseases all around the world, breast cancer is considered to be the commonest type- 18% of all (Warner 2011; Vo and Millis 2012)
Artemisinin, which is a terpene lactone taken from the leaves of Artemisia annua, is used as anti cancer drug (Yatuv et al 2010; Lai and Singh 2006)
Size measurement of nanoliposomes Mean diameter of nanoliposomal artemisinin was measured 500 nm and that of pegylated nanoliposomal artemisinin was 455 nm which was considered to be in nano dimension size
Summary
While cancer is known to be one of the widespread diseases all around the world, breast cancer is considered to be the commonest type- 18% of all (Warner 2011; Vo and Millis 2012). Artemisinin, which is a terpene lactone taken from the leaves of Artemisia annua, is used as anti cancer drug (Yatuv et al 2010; Lai and Singh 2006). Artemisinin molecule can damage the molecule and lead to the death of the cell (Lai and Singh 2006; Chen et al 2009). What is not to be neglected is its side effects Chadwick et al (2009). It seems practical to use nanocarriers in order to improve efficiency and paclitaxel toxic pattern. One of the controversial issues in nanotherapy concerns reduction or elimination of its side effects. Nanocarriers are used in nanotechnology as pioneer ones Peer et al (2007). In this study liposomes are used as lipid nanocarriers Riaz (1996)
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