Abstract
The aim of this study is the development of nanoemulsions for intravenous administration of Sorafenib, which is a poorly soluble drug with no parenteral treatment. The formulation was prepared by a high energy emulsification method and optimized by response surface methodology. The effects of overhead stirring time, high shear rate, high shear time, and cycles of high-pressure homogenizer were studied in the preparation of nanoemulsion loaded with Sorafenib. Most of the particles in nanoemulsion are spherical in shape, the smallest particle size being 82.14 nm. The results of the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole reveal that the optimum formulation does not affect normal cells significantly in low drug concentrations but could remove the cancer cells. Finally, a formulation containing Sorafenib retained its properties over a period of 90 days. With characterization, the study of the formulated nanoemulsion has the potential to be used as a parenteral nanoemulsion in the treatment of cancer. Graphical abstractSchematic figure of high pressure homogenizer device.
Highlights
Cancer is well known as a fatal disease
The advantage of nanotechnology has increased the number of research in this area and carriers of nanoemulsion have been found to be an effective method of resolving the issue of drug resistance to chemotherapy drugs for cancer [2]
There are many benefits attached to the drug delivery systems, which include the increase of drug stability in vivo, improved effects of
Summary
Cancer is well known as a fatal disease. It has been found that the rate of survival of cancer-stricken patients has not increased prominently over the last 30 years [1]. Among the key challenges in the successful treatment of cancer patients is the issue of drug resistance over a long period of time. The advantage of nanotechnology has increased the number of research in this area and carriers of nanoemulsion have been found to be an effective method of resolving the issue of drug resistance to chemotherapy drugs for cancer [2]. There are many benefits attached to the drug delivery systems, which include the increase of drug stability in vivo, improved effects of Izadiyan et al Chemistry Central Journal (2017) 11:21 rate in future biological studies. Nanoemulsion needs high-energy input, which is dissipated across massive areas during the process of emulsification [11]
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