Abstract
A recent application of microwaves in the healthcare area is for the rapid detection of bacterial spores, particularly of clinically significant spores such as Clostridium difficile. Here, we present a working model of C. difficile spore disruption by the action of a 2.45 GHz microwave electric field, independent of overall sample heating. The model shows how inner layers of the spore with the lower complex permittivity values will be subject to higher values of the electric field. The model also shows how the electric effects can be enhanced, focusing the electric field into “hotspots” using “angled” nanoparticles, yielding effective DNA release even at low microwave power levels. The model’s predictions have been validated through experimental results, which show an enhancement of DNA release from spores.
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