Abstract
In spite of a wealth of knowledge accumulated concerning the biochemical aspects of the mode of action of insecticides, little is known about the mechanism whereby the function of the nervous system, which is the major site of action of most insecticides, is affected and impaired. The only system that has been studied rather extensively in connection with the neurotoxic action of insecticides is cholinesterase. Since the bioelectric signal is the only parameter observable during nerve excitation, and also since the excitation does not directly depend on the metabolism in nerve as will be described later, electrophysiological experiments are most rewarding to elucidate the mechanism of action of insecticides on the nervous tissue.
Published Version
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