Abstract
The mechanism of the positive inotropic effect of prostaglandin F 2α (PGF 2α) was investigated using spontaneously beating isolated guinea pig atria. PGF 2α increased the contractile force in a concentration dependent fashion in a range between 10 −7M to 10 −5M. The maximal response to PGF 2α was obtained within 5 min and continued for at least 20 min. This positive isotropic effect of PGF 2α was not affected by verapamil, but was inhibited by procaine or TMB-8, potent inhibitors of Ca 2+ release from intracellular Ca 2+ compartments. Increase in extracellular Ca 2+ concentration failed to provoke a significant positive isotropic effect by PGF 2α, suggesting that this response is relatively independent of extracellular Ca 2+. These results suggest that the PGF 2α-mediated positive inotropic effect is produced by a mobilization of intracellular Ca 2+.
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