MO19-5 To establish a simulated hormonal microenvironment culture model for advancement of PDT modality in gynecological cancer

Abstract

Conventional studies using monolayer cell culture models for evaluating cancer treatment efficacies usually substantiated treatment effects due to neglection of the physiological and pathological effects inside the body. The use of single hormonal dose exposure to monolayer cells at a fixed duration for current hormonal studies limits the effects posed by the real physiological hormonal conditions for cancer growth in patients. This study aims to establish a simulated hormonal microenvironment culture model to mimic the hormonal changes inside body over times for better evaluation of ALA-based Photodynamic Therapy (PDT) in breast cancer.