Abstract
Context The biological behavior of multiple myeloma is determined by genetics and the marrow microenvironment. Inflammatory cells are the major sources of cytokines in MM-infiltrated bone marrow, and they can mediate immune suppression in MM. The current risk stratification for myeloma patients is mainly based on tumor biology, tumor burden, and patient characteristics. No factors related to inflammatory microenvironment have been enrolled. Objective Evaluate the prognostic value of cellular components of the systemic inflammatory response, including NLR, LMR, and PLR, on overall survival (OS) in MM patients. Design A retrospective study, including 190 MM patients who presented at our center during 2008–2019. Setting It was carried out in Oncology Center, Mansoura University (OCMU). Patients 190 patients with MM, with F/M (38.4%/61.6%) and mean age 57.22 ± 9.87 years. Interventions The patients were subjected to full laboratory and radiological assessments. Treatment was according to institute guidelines, dividing patients into transplant fit and unfit. Main Outcome Measures We determined the optimum cutoff points for the NLR, LMR, and PLR as predictors for OS based on the receiver operating characteristic (ROC) curve. Based on the cutoff values, the patients were categorized into the groups as follows: high-NLR group (≥1.99) and low-NLR group ( Results In this study, OS was significantly improved in patients without renal impairment (P=0.002), serum albumin >3.5 mg/dl (P=0.006), LDH ULN (P=0.215), PLR Conclusion Neutrophil/lymphocyte ratio and lymphocyte/monocyte ratio can be used in daily practice as a predictor for survival in multiple myeloma.
Published Version
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