Abstract
MK-801 is a noncompetitive antagonist to N-methyl-d-aspartate (NMDA) receptors. MK-801 was given (0.05 or 0.10 mg/kg i.v.) to rabbits during extinction of a well-established conditioned response (CR) in the nictitating membrane preparation. The drug administration produced an immediate deficit in CR performance during extinction. However, when MK-801 administration was suspended, CRs reappeared immediately and showed no evidence of the previous extinction treatment. In addition, we confirmed previous findings that MK-801 impairs both the acquisition and the expression of CRs during CS—US training. A reduction in CS processing caused by MK-801 is the most parsimonious explanation of the data. There are also two-factor alternatives, which contend that MK-801 directly hinders associative formation and either directly blocks CR output or produces a state-dependent generalization decrement.
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