Mixed-donor N,N,O-tridentate ligands for palladium-catalyzed Suzuki reactions

Abstract

Efficient Suzuki–Miyaura cross-coupling reactions of arylboronic acids with aryl halides catalyzed by Pd/N,N,O-tridentate ligands, using methanol as solvent and K3PO4 as base, afforded the corresponding cross-coupled biaryls in good to excellent yields. The Pd(OAc)2/N,N,O-tridentate ligands system was found to be very efficient for Suzuki reactions involving aryl bromides and activated aryl chlorides with arylboronic acid in methanol with K3PO4 as a base at 80 °C for 3 h. The mechanism of the Suzuki reactions along with the Suzuki-type self-coupling reaction catalyzed by these catalyst systems also proposed.