Abstract
During fetal development of the mitral valve, chordae tendineae are thought to derive from the leaflet after it’s delamination from the ventricular wall. However, preliminary work on the fetal bovine heart has shown the presence of branched chordae tendineae well before leaflet delamination (Fig. 1A). We hypothesized that the fetal chordae and leaflet tissue are developing along distinct timelines in the bovine heart. To test this hypothesis, we examined the anatomical development and extracellular matrix composition of the bovine mitral valve chordae and leaflet during fetal development and in adult.
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