Abstract
BackgroundThe aim of this study was to investigate early changes in left ventricular longitudinal systolic function in patients with hypertension (HTN) with and without concomitant diastolic dysfunction (DD) and the clinical implications of these findings.MethodWe enrolled 299 patients with HTN and 297 age-matched patients with HTN and DD and compared both groups with an age-matched control group consisting of 100 healthy subjects. The long axis systolic function was investigated by determining the average peak systolic velocity of the septal and lateral mitral sites (Smavg) using spectral pulsed wave tissue Doppler imaging (TDI).ResultsWe found a strong negative trend toward the reduction of velocity, which is dependent on the grade of HTN, on the magnitude of DD, and also on the gender and age of the subjects (r=−0.891/-0.580; p<0.0001). The data showed that the beginning and evolution of HTN are related to a slight but significant reduction in the long axis systolic function (10.2-10.0 cm/s; p<0.0001), and DD worsens this initial finding (9.8-8.8 cm/s; p<0.0001).ConclusionThe strength of the study is the analysis of incremental changes in longitudinal contraction in patients with different stage of HTN but not so many the classification of the degree of systolic dysfunction. The importance of our results lies in the fact that these initial changes in systolic contraction could be used as an early sign that should prompt optimization of the treatment of HTN.
Highlights
The aim of this study was to investigate early changes in left ventricular longitudinal systolic function in patients with hypertension (HTN) with and without concomitant diastolic dysfunction (DD) and the clinical implications of these findings
The dilemma is how to study this early changes in longitudinal systolic function
Discussion our study is not innovative in nature, as it repeats some of the conclusions achieved more than ten years ago, it confirms the hypothesis that in its development, HTN leads to early changes in the global systolic function of the left ventricular (LV)
Summary
The aim of this study was to investigate early changes in left ventricular longitudinal systolic function in patients with hypertension (HTN) with and without concomitant diastolic dysfunction (DD) and the clinical implications of these findings. HTN causes 5 million premature deaths a year worldwide It begins without clinical symptoms, which makes early diagnosis and treatment difficult. Later in the course of the disease, left ventricular (LV) hypertrophy and DD develop, if no some studies suggest that minimal systolic impairment in the longitudinal contraction of the LV contribute to the above mentioned symptoms in patients with HTN especially when DD is presented [4,5,6,7,8,9]. The dilemma is how to study this early changes in longitudinal systolic function
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