Mitral annular calcification predicts coronary artery disease in end-stage renal disease patients on hemodialysis

Abstract

Background Mitral annulus calcifi cation ( MAC) is a chronic, degenerative process of the fi brous support structure of the mitral valve. The reported prevalence of MAC is between 8 and 15%, but it signifi cantly increases with age and in patients with multiple cardiovascular risk factors or chronic kidney disease. Aim The aim of this study was to determine whether MAC predicts coronary artery disease in a group of end-stage renal disease patients. Patients and Methods Twenty-three patients with ESRD on hemodialysis referred for coronary angiography were prospectively studied. Results This study included 23 patients, MAC was seen in nine patients (39%). Seven patients had significant coronary artery disease (CAD) (30%). Ten patients had impaired left ventricular function (LVEF Conclusion MAC occurs in a proportion of patients with ESRD and is associated with increased mortality and the presence of significant CAD.