Abstract

AbstractMitochondria are the organelles as central hubs of energy production, apoptosis regulation, and Ca++ signaling, therefore prime targets of pathogens to destroy the signaling network as earliest for their survivability. Recently, several proteomics approaches have been undertaken for rapid identification and analyses of disease manifestation in infection biology. Here, we have summarized the mostly popular topdown proteomics approaches including methodology to available database for mitochondrial signaling network analyses during host-pathogen interaction and a key tool for rapid biomarker identification.

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