Mitochondrially Localized MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation

Abstract

Mitochondrially localized nucleus-encoded Ig-like v-type protein, MPZL3, regulates lipid metabolism, energy expenditure, as well as epidermal keratinocyte differentiation and function (Bhaduri et al., 2015; Leiva et al., 2014; Wikramanayake et al., 2021). Previous studies have shown increased energy expenditure and insulin sensitivity (Czyzyk et al., 2013), epidermal barrier defects and a seborrheic dermatitis–like inflammatory skin phenotype (Wikramanayake et al., 2017, 2018), as well as altered hair follicle cycling (Nicu et al., 2020) in Mpzl3 global knockout (GKO) (GKO–/–) mice.