Abstract
The sebaceous gland (SG) engages in holocrine secretion to produce lipid-rich sebum critical for epidermal barrier function, skin and hair lubrication, and microbiome management. SG undergoes continuous self-renewal to replenish differentiated sebocytes lost during holocrine secretion, as well as hair cycle-dependent oscillations in size. Previous studies have shown that a mitochondrially localized, nuclear encoded immunoglobulin-like v-type protein, Myelin Protein Zero-like-3 (MPZL3), regulates lipid metabolism and energy expenditure, as well as epidermal keratinocyte differentiation and function.
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