Abstract
The effect of a single dose of aflatoxin B, on the activities of chick liver mitochondrial enzymes, viz., succinate dehydrogenase, malatedehydrogenase and isocitrate dehydrogenase was studied, 24 hours after the administration of the toxin. A drastic reduction in the activities of the above enzymes was observed indicating mitochondrial injury due to aflatoxin toxicity. A significant decrease in the activities of transaminases was noted. A rise in the activities of serum alkaline phosphatase and serum aldolase of chicks together with a decrease in the activities of the liver enzymes are suggestive of impaired liver function in aflatoxin B1 poisoning.
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