Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men

Akatsuki Kokaze,Tadahiro Ohtsu,Hirotaka Ochiai,Takako Shirasawa,Masao Satoh,Yutaka Takashima,Masao Yoshida,Masayasu Hashimoto,Naoki Shimada,Hiromi Hoshino,Naomi Matsunaga,Mamoru Ishikawa,Kanae Karita

doi:10.1186/1476-511x-11-97

Akatsuki Kokaze, Tadahiro Ohtsu + Show 11 more

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https://doi.org/10.1186/1476-511x-11-97

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BackgroundSeveral genetic polymorphisms have been reported to modify the effects of smoking on serum lipid levels. The objective of this study was to investigate whether longevity-associated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese subjects.MethodsA total of 394 male subjects (age, 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effect of Mt5178 C/A polymorphism and cigarette smoking on the risk of hypo-high-density lipoprotein (HDL) cholesterolemia, hyper-low-density lipoprotein (LDL) cholesterolemia or hypertriglyceridemia was conducted.ResultsFor subjects with Mt5178C, the risk of hypo-HDL cholesterolemia increased with the number of cigarettes smoked daily (P for trend = 0.001). On the other hand, the association between Mt5178A genotype and the risk of hypo-HDL cholesterolemia did not appear to depend on the number of cigarettes smoked daily. For those with Mt5178A, the risk of hyper-LDL cholesterolemia or hypertriglyceridemia increased with cigarettes smoked daily (P for trend = 0.017 and P for trend = 0.002, respectively). However, the association between Mt5178C genotype and the risk of hyper-LDL cholesterolemia or hypertriglyceridemia did not depend on the number of cigarettes smoked daily.ConclusionsThe present results suggest that Mt5178 C/A polymorphism modulates the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.

Highlights

Prevention of Coronary heart disease (CHD) is one of the major public health issues
From analysis of published data, Craig et al concluded that habitual smoking is associated with significantly lower serum highdensity lipoprotein (HDL) cholesterol levels, and higher serum low-density lipoprotein (LDL) cholesterol levels and serum triglyceride levels [5]
This study aims to investigate whether longevityassociated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of hypo-HDL cholesterolemia, hyper-LDL cholesterolemia or hypertriglyceridemia in middle-aged Japanese male subjects

Summary

Introduction

Prevention of Coronary heart disease (CHD) is one of the major public health issues. The Global Burden of Disease Study showed that CHD is predicted as the leading cause of death in 1990 and in 2020 [1]. Populationbased follow-up studies showed that smoking is one of critical risk factors of CHD [2,3]. From analysis of published data, Craig et al concluded that habitual smoking is associated with significantly lower serum highdensity lipoprotein (HDL) cholesterol levels, and higher serum low-density lipoprotein (LDL) cholesterol levels and serum triglyceride levels [5]. From a crosssectional and longitudinal analysis in a large Japanese cohort, Kuzuya et al reported that serum LDL cholesterol levels are significantly lower in smokers than in nonsmokers [6]. Several genetic polymorphisms have been reported to modify the effects of smoking on serum lipid levels. The objective of this study was to investigate whether longevity-associated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese subjects

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