Abstract
Mitochondrial ATPase 6,8 Associated with Brain Tumours in Patients Compared to Adjacent Normal Brain Cells
Highlights
According to WHO, a primary brain tumour includes 160 types
This study is the first report on the association between ATPase 6,8 genes of mitochondria and the brain tumours
According to Mitomap, there are more than 30 mutations and sequence variations in mtDNA associated with brain tumours in mitochondrial genome database that have been reported
Summary
According to WHO, a primary brain tumour includes 160 types. The most common of these categories are gliomas and medulloblastoma. Gliomas are known by histological standards as consisting of the presence of mitoses, cytoplasmic morphology or devious nuclear, glomeruloid angiogenesis and necrosis. Based on the WHO classification system, gliomas can be categorized into four different grades with increasing malignancy apportion (Rich and Eyler, 2008). Treatments of malignant glioblastoma include surgical resection and radiation therapy, with some new studies in chemotherapy drugs, such as Temozolomide, Bevacizumab, Irinotecan, etc. Simultaneous use of these drugs with other treatments is more effective when compared with radiation therapy alone (Stupp et al, 2005, Vredenburgh et al, 2007). There are many studies about the relevance of the connection between mtDNA and well-known diseases like cancers and diabetes. Mitochondrial genes could participate in cancers—for example, breast, colon and kidney cancers (Raule et al, 2007)
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