Abstract
Identification of Single Nucleotide Polymorphisms as Markers of Genetic Susceptibility for Alopecia Areata Disease Risk
Highlights
In the study of two patient groups with AA and alopecia totalis (AT)/alopecia universalis (AU) was stated that 3 SNPs rs1701704 (T/T), rs9275572 (G/G) and rs694739 (T/T), a significant association with developing disease (p
Each of the ULBP genes has been shown to function as an NKG2D-activating ligand (Radosavljevic et al, 2002)
Disturbance in the hair follicle microenvironment ostensibly causes the initiation of AA
Summary
Abstract | Background: Alopecia areata (AA) is an autoimmune disease, leading to disfiguring hair loss that susceptibility loci and the genetic basis of AA have been largely unknown. Objective: The aim of this study was the scrutiny the susceptible genes of Alopecia areata amongst patients and healthy adult in Iranian populations. Methods: four variants polymorphisms (rs1701704, rs10760706, rs9275572, rs694739) were studied by Tetra Arms PCR, Sequencing methods in 200 Iranian healthy adult blood donors and 200 patients with Alopecia Areata (AA). Conclusions: In this study, 3 of 4 SNP-associated loci were associated significantly with association with the development of Alopecia areata. In another word, the presence of them may be a contributing factor for prognosis of the development of the disease to Totalis and Universalis. Keywords | Alopecia Areata (AA), Alopecia Universalis (AU), Alopecia Totalis (AT), autoimmune disease
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