Mitochondria, oxygen sensing, and the regulation of HIF-2α. Focus on “Induction of HIF-2α is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line”

Abstract

oxygen gradients in tissues and cells are critical signals in a range of physiological processes including development, wound healing, and adaptation to hypoxia ([12][1]). Eukaryotic cells have evolved mechanisms for sensing changes in local oxygen tension and initiation of a response designed to