Abstract
Background and Aim: Organophosphates are currently widely used by humans, but these compounds have tremendous negative effects on human health. Therefore, this study aims to use alpha-lipoic acid (ALA) to alleviate the negative effects of dimethoate (DM). Methods: This study was designed as follows: Thirty adult male Wistar albino rats were utilized and further subdivided into control, DM and DM+ALA groups. Liver and renal cortex sections from all groups were processed for histopathological examination and biochemical estimation of liver function tests, serum urea, creatinine, BUN, testosterone and lipid profile was performed. Results: This study clarified the ameliorative effects of ALA on the negative effects of DM, where ALA induced a significant recovery of hepatic (ALT, AST, ALP and total protein) and renal functions by normalizing them in the DM + ALA group and promoted some improvement of lipid profile and testosterone levels. Additionally, ALA restored normal hepatic and renal histomorphology. Conclusion: ALA therapy can be concluded to ameliorate the negative effects of DM that affect vital organs such as the liver and kidney. Additionally, ALA can reduce the occurrence of atherogenesis by decreasing the levels of unhealthy cholesterol in the blood. ALA also boosts testosterone levels, thus augmenting male sexual characteristics.
Highlights
Organophosphates (OPs), such as dimethoate (DM), have been a serious danger since World War II and have major involvement in a predicted thirty thousand instances of severe pesticide poisoning reported worldwide.[1]
The DM-treated group revealed a highly significant increase in the mean ALT, AST and Alkaline Phosphatase (ALP) levels compared to the control group (P < 0.01), it showed a significant decrease in the mean Total Protein (TP) level
The DM+alpha-lipoic acid (ALA) group exhibited a significant decrease in the mean ALT, AST and ALP (P < 0.01) levels compared to the DM-treated group, while it showed a significant increase in the mean TP level (P
Summary
Organophosphates (OPs), such as dimethoate (DM), have been a serious danger since World War II and have major involvement in a predicted thirty thousand instances of severe pesticide poisoning reported worldwide.[1]. Influenza-like conditions with headache, nausea, weakness, loss of appetite and malaise have been reported.[4] Dimethoate disturbs the functions of multiple organs, including the liver.[5] The liver is the primary organ involved in metabolism and is a target organ of OPs and drugs. This study aims to use alpha-lipoic acid (ALA) to alleviate the negative effects of dimethoate (DM). Liver and renal cortex sections from all groups were processed for histopathological examination and biochemical estimation of liver function tests, serum urea, creatinine, BUN, testosterone and lipid profile was performed. Results: This study clarified the ameliorative effects of ALA on the negative effects of DM, where ALA induced a significant recovery of hepatic (ALT, AST, ALP and total protein) and renal functions by normalizing them in the DM + ALA group and promoted some improvement of lipid profile and testosterone levels.
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