Mismatch Negativity Responses to Different Auditory Attributes in Normally Developing Infants and Children.

Abstract

Introduction Mismatch negativity (MMN) is a change-specific component of the event-related potentials that is elicited by an irregularity in repetitive auditory stimulation. As it is developmentally stable and can be measured in the absence of the participant's attention, it can be a valuable method for assessing auditory discrimination in infants and young children. The classic MMN paradigm involves tone frequency as the mismatching attribute. Multi-feature MMN paradigms which involvedifferent auditory attributes can assess discrimination abilities in a wider group of disorders. The study aimed to report standardised MMN values obtained with MMN paradigms including several auditory attributes to extend the clinical applicability of the test in infants and young children. Methods MMN responses were recorded in 42 normal infants and young children (2 months to 5 years) with multi-feature MMN paradigms. MMN variables in different trials were compared by one-way ANOVA. Pearson's correlation coefficient and independent sample t-test were performed for finding an association with the age and gender of the participants respectively. P<0.05 was considered as statistically significant. Results MMN amplitude exhibited statistically significant differences in different MMN paradigms (p<0.05). An increase in the degree of standard and deviant differences and double deviant responses also resulted in larger MMN. MMN latency variation in the trials was not statistically significant. The age and gender of the participants did not influence the MMN variables with statistical significance. Conclusion MMN paradigms with different auditory attributes report significant amplitude variations. Multi-feature MMN paradigms can optimize the clinical applicability of the test and can determine the profile of different auditory discrimination abilities.