Abstract
“The epidemiological findings and the accumulating data on the protective effects of deferoxamine in myocardial injury are consistent with the iron depletion hypothesis. The hypothesis implies that ferritin is a risk factor for IHD but does not precisely define the epidemiological behavior of ferritin as a risk factor. The hypothesis focuses on protective effects of iron depletion, a state in which there is essentially no ferritin present. The hypothesis does not, and with available data, cannot adequately address the quantitative aspects of the relationship between ferritin and incidence of IHD. The strength of serum ferritin as a risk factor for IHD may
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