Abstract
ABSTRACTA series of poly(acrylic acid)/poly(methyl vinyl ketone) (PAA/PMVK) blends with different compositions were prepared by the solvent casting method. The miscibility of this pair of polymers was investigated by differential scanning calorimetry(DSC), Fourier transform infra-red (FTIR) and X-Ray diffraction (XRD) techniques. An in-vitro cytotoxicity test of the drug-carrier system via MTT (3-(4,5-demethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed no significant cytotoxic effects at concentrations up to 100 µg· ml−1. The STX/PAA-50 drug carrier systems were also prepared by solvent casting of solutions containing the sulfamethoxazole (STX) used as drug model and PAA/PMVK blend in N.N-dimethylformamide then crosslinked with acidified ethylene glycol. The release dynamic of STX from the prepared hydrogels was investigated in which the diffusion through the polymer matrix, the enhancement of the water solubility of STX, the influence of the initial drug concentration, the pH of the medium, and the effect of the degree of swelling of the polymer matrix on the release dynamic was evaluated. According to the total gastrointestinal transit time estimated by Belzer, the estimate distribution of STX released in the different organs indicated that the performance is obtained with the drug – carrier-system containing equal ratios of polymer and 10 wt% of STX (STX-10/PAA-50).
Highlights
The use of synthesized polymers in the biomedical domain gained considerable attention from different researchers in the last decade [1,2,3,4,5,6,7,8]
As it can be seen that with STX-10/Poly(acrylic acid) (PAA)-50 hydrogel, the maximum solubility of this drug is 371.36 ± 068 mg.L−1 at neutral media pH and 99.80 ± 08 mg.L−1at pH1.This finding confirms the results of the differential scanning calorimetry (DSC) and X-Ray diffraction (XRD) analyses in which STX particles incorporated in the PMAA/Poly(methyl vinyl ketone) (PMVK) matrix are found
The miscibility of PAA/PMVK is effectively proved by DSC and Fourier transform infra-red (FTIR) methods The DSC, XRD and SEM analyses revealed that the STX particles incorporated in the blend by solvent casting are uniformly distributed in the polymer matrix in their molecules state
Summary
Müller et al [29] investigated the oral drug delivery application of mucus-penetrating papain combined with a PAA nanoparticle composite (PAPC). This system showed remarkable ability to cleave the mucogly-co-protein substructures responsible for the structural and rheological properties of mucus. The study revealed that the substituent carboxyl groups of poly(acrylic acid) interact strongly with the proton acceptors of the glucose units in dextran This copolymer showed a smart pH response, where they shrank in acidic media and swelled in high-pH media. The pH-dependent response of acrylic acid-based polymers were investigated as controlled drug carrier systems.
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