MIS (Кавасакі-подібний мультисистемний запальний синдром) як прояв SARS-CoV-2 у новонароджених від матерів, що перехворіли на COVID-19 під час вагітності: огляд літератури

Abstract

The coronavirus disease (COVID-19) has become a global problem for countries all over the world. People of all age groups are prone to infection and newborns make no exception. Рurpose - to analyze and summarize information on the characteristics of the course, clinical manifestations, complications and ways to overcome coronavirus infection in newborns from mothers who contracted COVID-19 during pregnancy. The results of clinical observations of this pathology in the perinatal period are of particular interest to doctors of related specialties, because the question simultaneously concerns the life of the mother and her child. The article in particular is an attempt to tackle changes in the “mother–fetus–newborn” system under the influence of the virus. SARS-CoV-2 causes a clinical syndrome in babies, called Multisystem Inflammatory Syndrome in Newborns and Children (MIS-N, MIS-C - Multisystem Inflammatory Syndrome - depending on the age of the child). It occurs after an acute infection with COVID-19, the clinical picture is very similar to Kawasaki disease and manifestations of multiple organs failure in infants. The article analyzes the latest data from foreign and domestic literature of publicly available scientific sources, which present modern views on the clinical features of the course of COVID-19 in the context of Kawasaki-like multisystem inflammatory syndrome in newborns, summarizes the issues of etiology, pathogenesis, features of clinical manifestations of coronavirus infection in newborns, as well as diagnosis and disease management options in the neonatal period. No conflict of interests was declared by the authors.