Abstract
Background: Accumulating studies have focused on the relationship between miRNAs polymorphisms and cancer prognosis. However, the results are conflicting and unconvincing. This systematic review and meta-analysis was conducted to explore the relationship between miRNAs polymorphisms and cancer prognosis, aiming to seek for markers with cancer prognostic function.Methods: Hazard ratio of overall survival, disease-free survival (DFS) and recurrence-free survival were calculated to evaluate the association between miRNAs polymorphisms and cancer prognosis by using Stata software 11.0.Results: We systematically reviewed the association of 17 miRNAs SNPs with cancer prognosis including 24,721 samples. It was shown that 6 miRNAs SNPs (miR-608 rs4919510, miR-492 rs2289030, miR-378 rs1076064, miR-499 rs4919510, miR-149 rs2292832, miR-196a2 rs11614913) were associated with better cancer overall survival (OS) while let-7i rs10877887 was associated with poor OS; the homozygous and heterozygote genotype of miR-423 were related to poor cancer relapse-free survival (RFS) when compared with the wild genotype; miR-146 rs2910164 was linked to favorable cancer DFS while miR-196a2 rs11614913 was associated with poor DFS.Conclusions: In summary, let-7i rs10877887, miR-608 rs4919510, miR-492 rs2289030, miR-378 rs1076064, miR-423 rs6505162, miR-499 rs4919510, miR-149 rs2292832, miR-146 rs2910164, and miR-196a2 rs11614913 might serve as potential biomarkers for cancer prognosis.
Highlights
Despite emerging advances in the researches and understanding in tumor biology, cancer incidence remains rising and this global challenge further exacerbates by the increasing human life expectancy [1]
The original miRNA SNPs and Cancer PrognosisMicroRNAs (miRNAs) SNPs and Cancer Prognosis no significant relationship was indicated between rs4919510 and cancer disease-free survival (DFS) (Tables 2–4)
The AC vs. CC and AC+AA vs. CC models indicated poor cancer prognosis (HR = 1.34, 95%confidence interval (CI) 1.03–1.73, p = 0.026; hazard ratio (HR) = 1.37, 95%CI 1.01–1.86, p = 0.042, respectively) and we found no significant heterogeneity of these two SNPs (I2 = 24.1%, p = 0.268; I2 = 29.0%, p = 0.235, respectively Table 3)
Summary
Despite emerging advances in the researches and understanding in tumor biology, cancer incidence remains rising and this global challenge further exacerbates by the increasing human life expectancy [1]. MicroRNAs (miRNAs), a class of non-coding RNAs with 19– 25 nucleotides length, are small and regulatory RNAs binding to the 3′-UTR region of mRNA molecules. They have been regarded as key regulators in many diseases, relevant in cancer [3, 4]. Accumulating studies have focused on the relationship between miRNAs polymorphisms and cancer prognosis. This systematic review and meta-analysis was conducted to explore the relationship between miRNAs polymorphisms and cancer prognosis, aiming to seek for markers with cancer prognostic function
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
