Abstract
Recently extensive focus has been concentrated on the role of miRNAs in the initiation and progression of cardio-cerebrovascular diseases (CCDs) which constitute a range of conditions including cardiovascular diseases (CVDs, especially coronary artery disease (CAD)), congenital heart disease (CHD) and cerebrovascular diseases (CBVDs, especially the ischemic stroke (IS)). An increasing number of studies are evaluating the association between different miRNA polymorphisms and risk of CCDs, but results have been inconclusive. This study represents a comprehensive systematic review and meta-analysis of the association between miRNA polymorphisms and risk of CCDs. PubMed, Embase, Scopus, and Web of Science were queried to identify eligible articles. Odds ratios and 95% confidence intervals were used to assess the association of miRNA polymorphisms with CCD susceptibility. A total of 51 eligible articles evaluating the association of 31 miRNA polymorphisms were identified. Meta-analysis was performed for six miRNA polymorphisms. miR-146a rs2910164 (30 studies: 13,186 cases/14,497 controls), miR-149 rs2292832 (Nine studies: 4116 cases/3511 controls), miR-149 rs71428439 (Three studies: 1556 cases/1567 controls), miR-196a2 rs11614913 (20 studies: 10,144 cases/10,433 controls), miR-218 rs11134527 (Three studies: 2,322 cases/2,754 controls) were not associated with overall CCD. miR-499 rs3746444 was associated with CCD (20 studies: 9564 cases/8876 controls). In the subgroups, rs2910164 and rs3746444 were only associated with CVDs, especially CAD. In conclusion, the results support the existence of a role for miR-146a rs2910164 and miR-499 rs3746444 in determining susceptibility to CCDs, especially CAD.
Highlights
Cardio-cerebrovascular diseases (CCDs) consist of several clinically heterogeneous medical conditions which are among the leading causes of death worldwide
A total of 3730 articles were excluded, in which 1192 articles were duplicates, 1210 articles were not association studies, 68 articles were abstracts or conference meetings, 22 articles were systematic review/meta-analysis, 1048 articles were review manuscript, 15 articles were not written in English, 96 articles were related to other diseases, and 79 articles were related to other genes or polymorphisms
A total of 31 miRNA polymorphisms were evaluated in these articles (Table 1 and Table S1)
Summary
Cardio-cerebrovascular diseases (CCDs) consist of several clinically heterogeneous medical conditions which are among the leading causes of death worldwide. Despite significant recent developments in prevention, diagnosis and clinical management, cardiovascular diseases (CVDs) and cerebrovascular diseases (CBVDs) remain a major challenge imposing a heavy burden on healthcare systems. A stroke is a clinically important manifestation of CBVD that is presumed to be of vascular origin and is characterized by rapidly developing signs of focal or global disturbance of cerebral functions lasting >24 h or leading to death [1]. In most cases, it is caused by an ischemic stroke (IS) and cerebral infarction
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