MiR-19a as a prognostic indicator for cancer patients: a meta-analysis.

Yizhong Peng,Zengwu Shao,Xiangyu Deng,Kaige Ma,Donghua Huang

doi:10.1042/bsr20182370

Yizhong Peng, Zengwu Shao + Show 3 more

Open Access

https://doi.org/10.1042/bsr20182370

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Abstract

MiR-19a was aberrantly expressed in various types of cancers and was observed to be potentially associated with the prognosis of cancer patients. The present analysis aims to elucidate its precise predictive value in various human malignancies. Online electronic searches of PubMed, Web of Science (WOS), Embase in English and VIP, Wanfang, SinoMed, and the China National Knowledge Infrastructure (CNKI) in Chinese up to September 8, 2018 were conducted. As a result, in overall analysis, a significant association was identified between miR-19a levels and OS (HRs = 2.31, CI: 1.11–4.83). The relation of miR-19a expression to OS was further recognized by fixed model within the studies of sample size less than 150 (HRs = 1.68, CI: 1.35–2.08), NOS scores greater than or equal to 8 (HRs = 1.53, CI: 1.13–2.06) or less than 8 (HRs = 1.89, CI: 1.58–2.27), specimen derived from tumor (HRs = 1.73, CI: 1.42–2.12) or blood (HRs = 1.87, CI: 1.46–2.40) and the patients of osteosarcoma (HRs = 7.17, CI: 5.04–10.21). Sensitivity analyses revealed no significant results. The association between miR-19a expression level and DFS was also found to be significant (HRs = 2.03, CI: 1.13–3.66). Correlations between miR-19a levels and clinicopathological features were examined and revealed that lymph node metastasis was significantly associated with miR-19a expression levels (OR = 0.565, CI: 0.346–0.921). Summarily, the over expression of miR-19a was an underlying risk of poor prognosis in many human malignancies, especially in osteosarcoma. Moreover, elevated miR-19a expression was linked to the potential of lymph node metastasis.

Highlights

Cancer which is a multi-factorial disease has been one of the most common causes of death world mortality [1]
Studies from the initial searches that satisfy the criteria below are thought to be eligible. (1) associations of miR-19a expression levels with prognosis or clinicopathological features were reported; (2) describing the outcomes, which include overall survival (OS), recurrence-free survival (RFS), progression-free survival (PFS), or disease-free survival (DFS); (3) patients were dichotomized into two groups in terms of high and low expression levels of miR-19a; (4) the miR-19a expression levels in the cancer patients were measured by some specific methods, such as real-time polymerase chain reaction (qRT-PCR), microarray, etc
Eight studies measured the miR-19a expression level by qRT-PCR, while three studies applied the methods of miRNA array

Summary

Introduction

Cancer which is a multi-factorial disease has been one of the most common causes of death world mortality [1]. In 2012, the world estimated incidence and death rate are 14.09 million and 8.2 million, respectively [2]. By negatively regulating the expression of their target genes at the post-transcriptional level, miRNAs can control a wide variety of physiological functions including cellular proliferation, differentiation, and apoptosis [5]. Many miRNAs have been reported to be aberrantly expressed in carcinomas and can operate either tumor-promoting or tumor-suppressing functions [6,7]. Regulated miRNAs have promoted considerable interest in applying them as prognostic markers and therapeutic targets for human cancers [10]

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