Abstract
BackgroundThe common polymorphism rs11614913 in miR-196a2 might be associated with lung cancer risk for non-smoking females in northeast China.MethodsThe genotypes of rs11614913 in miR-196a2 were determined by a case-control study including 1003 patients with lung cancer and 1003 healthy controls. The tissues were detected to assess the miRNA expression. Secondary structures of miR-196a2 were predicted.ResultsThere was a significant association between miR-196a2 rs11614913 and lung cancer risk in Chinese non-smoking females. Individuals carrying TC or CC genotype had increased risk of lung cancer compared with TT genotype (adjusted risks were 1.63 and 1.67). The C allele was associated with a higher risk of lung cancer with a significant risk of 1.27. The similar significant results were also found in lung adenocarcinoma. There was a significant association between miR-196a2 expression and lung cancer risk (t=2.594, P=0.012). The relative expression of miR-196a2 was significantly higher for CC genotype comparing with the CT or TT genotype in tumor tissues (P values were all 0.003). The optimal free energies were different for T allele and C allele.ConclusionsThe polymorphism rs11614913 in miR-196a2 may be associated with lung cancer risks in Chinese non-smoking females through affecting miR-196a2 expression and secondary structure.
Highlights
Based on GLOBOCAN estimates, about 1.8 million new lung cancer cases occurred in 2012, accounting for about 13% of total cancer diagnoses [1]
There was a significant association between miR-196a2 rs11614913 and lung cancer risk in Chinese non-smoking females
The polymorphism rs11614913 in miR-196a2 may be associated with lung cancer risks in Chinese non-smoking females through affecting miR-196a2 expression and secondary structure
Summary
Based on GLOBOCAN estimates, about 1.8 million new lung cancer cases occurred in 2012, accounting for about 13% of total cancer diagnoses [1]. Lung cancer was the second leading cause of cancer death in less developed countries. Lung cancer rates in Chinese women (20.4 cases per 100,000 women) were higher than rates among women in some European countries despite a lower prevalence of smoking, suggesting that in addition to tobacco, there are other impact factors involved in the etiology of lung cancer, especially for women [1]. Molecular epidemiologic studies have shown that there were hundreds of genes involved in lung carcinogenesis and newly developed biomarkers such as noncoding small RNAs may lead to novel understanding in the molecular mechanisms of lung cancer [2]. MicroRNAs (miRNAs) are a class of small (about 21- to 24-nucleotide long) noncoding RNAs, which are considered to influence gene expression at the post transcriptional level. The common polymorphism rs11614913 in miR-196a2 might be associated with lung cancer risk for non-smoking females in northeast China
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