Abstract
Nef gene sequences were analysed in HIV-1-infected patients, immunised with a single nef gene or a combination of nef, rev and tat genes. After three to six immunisations, we found no increase of amino acid substitutions within predicted cytotoxic T-cell epitopes, compared with epitopes located outside predicted sites. The lack of immune escape variants was seen despite significantly increased nef-specific cytotoxic responses. Immunogenicity may have been of too short a duration to cause persistently detectable escape mutants.
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