Mining and Biosynthesis of Bioactive Lanthipeptides From Microorganisms

Caiyun Li,Jinfang Hao,Yiming Zhao,Aiying Li,Youming Zhang,Ruijuan Li,Khorshed Alam,Qing Yang

doi:10.3389/fbioe.2021.692466

Abstract

Antimicrobial resistance is one of the most serious public health issues in the worldwide and only a few new antimicrobial drugs have been discovered in recent decades. To overcome the ever-increasing emergence of multidrug-resistant (MDR) pathogens, discovery of new natural products (NPs) against MDR pathogens with new technologies is in great demands. Lanthipeptides which are ribosomally synthesized and post-translationally modified peptides (RiPPs) display high diversity in their chemical structures and mechanisms of action. Genome mining and biosynthetic engineering have also yielded new lanthipeptides, which are a valuable source of drug candidates. In this review we cover the recent advances in the field of microbial derived lanthipeptide discovery and development.

Highlights

With the emergence of multidrug-resistant (MDR) pathogens, antimicrobial resistance for many clinically-used antibiotics, even the most famous daptomycin, has been reported (Heidary et al, 2018)
The frequent rediscovery of known compounds triggered a drastic decrease in new antibiotic detection using traditional drug discovery pipelines and only around 30 antibiotics were approved as new drugs during the last two decades (Weber, 2016; Butler et al, 2017)
Several new important antibiotics reported in recent years, such as cadasides, malacidins and teixobactin, are all peptides with defense capability against a variety of MDR bacteria and without antimicrobial resistance by far (Ling et al, 2015; Guo et al, 2018; Hover et al, 2018; Wu et al, 2019)

Summary

Introduction

With the emergence of multidrug-resistant (MDR) pathogens, antimicrobial resistance for many clinically-used antibiotics, even the most famous daptomycin, has been reported (Heidary et al, 2018). Since the discovery of nisin in 1928, about a little more than one hundred of lanthipeptides have been reported from microorganisms, and they display complex and highly diverse structures and bioactivities (Figure 1; van Staden et al, 2021).

Results

Conclusion