Abstract
The purpose of this study was to find the minimum inhibitory concentrations (MIC) for the following antibacterial agents: chloramphenicol, florfenicol, flumequine and the combination trimethoprim/sulfadiazine to bacteria associated with scallop ( Pecten maximus) larvae. To evaluate possible effects of components in seawater to the antimicrobial activity of these agents, MIC values were established on Mueller Hinton agar dissolved in either distilled water added 2% NaCl or 25‰ seawater. For flumequine and trimethoprim/sulfadiazine, the MIC values increased significantly using 25‰ seawater compared to 2% NaCl. Chloramphenicol and florfenicol did not show any significant increase in MIC values using 25‰ seawater compared to 2% NaCl. A significant increase in MIC values was found for chloramphenicol in the second egg group, using 25‰ seawater compared to 2% NaCl. It is concluded that flumequine, trimethoprim/sulfadiazine and chloramphenicol are, to a varying degree, antagonised by components in seawater.
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