Abstract
Ficus lyrata Warb is a part of the genus Ficus, which in its utilization is only limited as a shade plant on the roadside. The Ficus lyrata Warb leaves and fruits contain bioactive compounds, namely flavonoids, phenolic compounds, and tannins, which have the potential to be an antimicrobial. The antimicrobial activity of leaf extracts of Ficus lyrata Warb against Escherichia coli has already known in previous studies. However, the study about antimicrobial activity of leaf and fruit extracts of Ficus lyrata Warb tree against Salmonella typhi is still not known until now. This research aims to obtain the antimicrobial activity of leaf and fruit extracts of Ficus lyrata Warb and to determine Minimum Inhibitory Concentration (MIC) against Salmonella typhi. The method used for antibacterial activity testing was the disc diffusion method, and the determination of MIC was carried out by the microdilution method using spectrophotometric UV-Vis analysis. The inhibition zone data were analyzed using one way ANOVA and Least Significant Differences (LSD). An independent t-test was used for pairwise comparison. The results showed that there were effects of fruit and leaf extracts on the growth of Salmonella typhi bacteria and each concentration of the extracts have a significant difference, compared to the positive control. The MIC test results using spectrophotometry with two replications showed that the fruit MIC value of 1.56% and the leaf MIC value was 6.25%.
Published Version
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