MiniControl 2.0: Co-Synthesis of Flow and Control Layers for Microfluidic Biochips With Strictly Constrained Control Ports

Abstract

Recent advances in continuous-flow microfluidics have enabled highly integrated lab-on-a-chip biochips. These chips can execute complex biochemical applications precisely and efficiently within a tiny area, but they require a large number of control ports and the corresponding control logic to generate required pressure patterns for flow control, which, consequently, offset their advantages and prevent their wide adoption. In this article, we propose the first flow-control layer co-synthesis flow called MiniControl, for continuous-flow microfluidic biochips under strict constraints for control ports, incorporating high-level synthesis, physical design, and control system design simultaneously, which has never been considered in previous work. With the maximum number of allowed control ports specified in advance, this synthesis flow aims to generate biochip architectures with high execution efficiency and the corresponding control systems with optimized timing performance. Besides, the overall cost of a biochip can be reduced and the tradeoff between a control system and execution efficiency of biochemical applications can be evaluated for the first time. The experimental results demonstrate that MiniControl leads to high execution efficiency, low platform cost, as well as excellent timing performance, while strictly satisfying the given control-port constraints.