Abstract
A method based on micro-matrix solid-phase dispersion (μ-MSPD) followed by gas-chromatography tandem mass spectrometry (GC–MS/MS) was developed to analyze UV filters in personal care products. It is the first time that MSPD is employed to extract UV filters from cosmetics samples. This technique provides efficient and low-cost extractions, and allows performing extraction and clean-up in one step, which is one of their main advantages. The amount of sample employed was only 0.1 g and the extraction procedure was performed preparing the sample-sorbent column in a glass Pasteur pipette instead of the classic plastic columns in order to avoid plastizicer contamination. Factors affecting the process such as type of sorbent, and amount and type of elution solvent were studied by a factorial design. The method was validated and extended to other families of cosmetic ingredients such as fragrance allergens, preservatives, plasticizers and synthetic musks, including a total of 78 target analytes. Recovery studies in real sample at several concentration levels were also performed. Finally, the green extraction methodology was applied to the analysis of real cosmetic samples of different nature.
Highlights
The cosmetic industry is one of the fastest growing markets in the world, due to a high demand for cosmetics and personal care products
The chromatographic GC–MS/MS method for the determination of the target UV filters was previously proposed by the authors [16,17,18], and it was extended to other compounds including
A new analytical methodology based on μ-matrix solid-phase dispersion (MSPD)-GC–MS/MS has been proposed for the first time for the simultaneous analysis of 14 multiclass organic UV filters in cosmetic and personal care products
Summary
The cosmetic industry is one of the fastest growing markets in the world, due to a high demand for cosmetics and personal care products. Cosmetic formulations usually include a large number or organic compounds, such as fragrances, preservatives, antioxidants, plasticizers, or surfactants among others. One type of these compounds are the ultraviolet filters (UV filters). These substances are intended to protect consumers against the harmful solar radiation and, their presence is especially important in sunscreens, they can be found in a broad range of daily care products such as creams, hair-care products, lip protectors, make-up, and many others. The widespread inclusion of UV filters in personal care and consumer products increases the human exposure to these compounds. Nowadays, according to the Annex VI of the Regulation EC No 1223/2009 [1], 26 organic UV filters are allowed for Separations 2019, 6, 30; doi:10.3390/separations6020030 www.mdpi.com/journal/separations
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