Abstract
AbstractAs a basic operation of mechanical process engineering, pressure filtration and its scale‐up has been described in detail in the literature. But, the pharmaceutical development of active substances, in particular, calls for a scale‐up of relatively small quantities to execute downstream processes in a lean and reliable manner. Therefore, development depends on conclusions from smaller filter equipment. In this study, results from laboratory nutsche filters with filter surface areas of 1.4 cm2 and 9.6 cm2 were compared with results from a 20 cm2 nutsche. It has been shown that no reproducible and reliable data could be generated using the 1.4‐cm2 nutsche. While this was possible using the 9.6 cm2 nutsche, the permeability was greater than with the recommended 20 cm2 nutsche so that a correction factor has to be introduced.
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