Mineral disturbances in patients with CKD: A case control study

Abstract

Mineral bone Disease in CKD manifest as a combination of abnormalities of PTH, calcium, phosphorus and vitamin D metabolism. Abnormalities of bone turnover, mineralization, Vascular or other soft tissue calcification. Mineral disturbances are common complications of CKD they begin early in the course of disease. Derangements in mineral metabolism is also associated with cardiovascular disease and all-cause mortality. Cardiovascular disease accounts for 70% of all deaths in patients with CKD, with an overall mortality of 20% per year in patients on dialysis. 50 patients diagnosed with CKD and 50 healthy controls were included in the study. Serum calcium, Serum Phosphorus, Serum PTH, Serum urea and Serum creatinine were estimated in both cases and controls.: Statistically significant increase in calcium and phosphorus levels were seen in cases as compared to controls. The mean level of calciumin cases is 8.35±1.07 and control is 8.98±0.98 and the mean level of phosphorus in cases is 4.40±1.70 and control is 3.47±0.62 (p<0.001). Alteration in minerals like calcium and Phosphorus occurs early in the course of disease and are responsible for various cardiovascular manifestations and bone osteodystrophy. Early medical management like calcium supplementation and phosphate binders help in better management of Mineral bone disease in CKD.