Abstract

Diabetes is a metabolic disorder with numerous complications. Combining herbal therapy appears to help treat type 2 diabetes and its complications. The focus of this research was to develop a polyherbal anti-diabetic formulation with an ethanolic extract of Gymnema sylvestre, Murraya koenigii, Cinnamomum verum, Phyllanthus emblica , and Syzygium cumini and to assess its phytochemical constituents, antioxidant activity (DPPH, ·OH, O2·, and reducing power). In vitro anti-diabetic activity of polyherbal extracts was also investigated. The mineral content of the formulation was estimated using ICP-MS. The polyherbal formulation contained a high concentration of polyphenols and flavonoids. It also had good antioxidant properties and significant -glucosidase and -amylase activities when compared to the standard drug acarbose. However, more research using an in vivo model is needed to determine the effect of free radicals and anti-diabetic activity in the treatment of type 2 diabetes. .

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