Abstract
Huntington disease (HD) is a hereditary neurodegenerative disease that results in impairment of brain function. HD is associated with expanded trinucleotide repeats in the huntingtin (HTT) gene, which translate into polyglutamine (polyQ) stretches within the huntingtin protein (Htt). Researchers have hypothesized that expanded polyQ domains promote aggregation of Htt, which leads to neurodegeneration in HD patients. In the January 18 issue of the Proceedings of the National Academy of Sciences, Zhang et al. identify organic compounds that inhibit polyQ aggregation in brain slices and block their neurodegenerative effects in a Drosophila melanogaster model of HD.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
