Abstract
AimsWe examined whether the milk + carbohydrate (CHO) supplementation during interval walking training improved the symptoms of lifestyle‐related diseases with enhanced methylation of the pro‐inflammatory gene, NFKB2.MethodsTwenty nine subjects (~70 yr) having performed interval walking training for >6 months but with >130 mmHg of systolic pressure and >110 mg/dl of blood glucose participated in the study. After the baseline measurements of peak aerobic capacity (VO2peak) by graded walking test, blood constituents, blood glucose by continuous method (iPro2R), and carotid arterial compliance with Doppler ultrasound (Vivid7R) and non‐invasive arterial pressure measurement (FinometerR), we randomly divided subjects into two groups: MILK (6 men, 9 women) and CNT (6 men, 8 women) consuming either milk (10 g protein and 9.5 g CHO) + CHO (8.8 g) or CHO (7 g) alone during 5‐month interval walking training, respectively. After the training, we measured the same variables as before.ResultsIn MILK, VO2peak and carotid arterial compliance increased and mean blood glucose decreased with a reduced fluctuation after standardized meal intake during the day (all, P<0.05); however, these changes were minimal in CNT (all, P>0.06). This was accompanied by enhanced methylation of NFKB2 in MILK than CNT (P=0.045).ConclusionsMilk + CHO supplementation during interval walking training enhanced the improvement of lifestyle‐related diseases with enhanced NFKB2 methylation.Support or Funding InformationThis study was supported by a grant from the Japan Society for the Promotion of Science (15H01830).This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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