Abstract
BackgroundGlioma is a common brain tumor with a high mortality rate. A small population of cells expressing stem-like cell markers in glioma contributes to drug resistance and tumor recurrence.MethodsPorous silicon nanoparticles (PSi NPs) as photothermal therapy (PTT) agents loaded with TMZ (TMZ/PSi NPs), was combined with hyperbaric oxygen (HBO) therapy in vitro and in vivo. To further investigate underlying mechanism, we detected the expression of stem-like cell markers and hypoxia related molecules in vitro and in vivo after treatment of TMZ/PSi NPs in combination with PTT and HBO.ResultsNCH-421K and C6 cells were more sensitive to the combination treatment. Moreover, the expression of stem-like cell markers and hypoxia related molecules were decreased after combination treatment. The in vivo results were in line with in vitro. The combination treatment presents significant antitumor effects in mice bearing C6 tumor compared with the treatment of TMZ, PTT or TMZ/PSi NPs only.ConclusionThese results suggested the TMZ/PSi NPs combined with HBO and PTT could be a potential therapeutic strategy for glioma.
Highlights
IntroductionA small population of cells expressing stem-like cell markers in glioma contributes to drug resistance and tumor recurrence
Glioma is a common brain tumor with a high mortality rate
Increasing evidences have indicated the existence of a small population of glioma cells with stem cell properties, referred to as glioma stem-like cells, which contribute to therapy resistance, poor prognosis, and tumor recurrence [6, 7]
Summary
A small population of cells expressing stem-like cell markers in glioma contributes to drug resistance and tumor recurrence. Increasing evidences have indicated the existence of a small population of glioma cells with stem cell properties, referred to as glioma stem-like cells, which contribute to therapy resistance, poor prognosis, and tumor recurrence [6, 7]. Hypoxia is an important characteristic of solid tumors and plays a significant role in stem-like cell development [8]. Used anti-tumor drug TMZ against glioma increases the medial survival of the patient for only several months, which may happen due to chemoresistance under the hypoxia related environment [12, 13]. HBO could overcome the hypoxia microenvironment in solid tumor and increase the sensitivity of tumor cell to chemotherapy [14, 15]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
