Mild Systemic Zinc Imbalance Delays Recovery in a Mouse Model of Surgically-Induced Ileus: Is it Driven by Disturbances in the Cytokine Network or Pro-Inflammatory Components of the Lipidome?

Abstract

mice. These findings were confirmed by inhibiting the P2X7 receptor with oxi-ATP (40 mg/kg i.p.). Inhibition of P2X7 receptors led to increased bacterial burden, cytokine and chemokine levels in septic shock. P2X7KO/P2X7WT bone marrow chimeras exhibited higher cytokine and chemokine levels than P2X7WT/P2X7WT mice. Septic P2X7KO mice had excessive apoptosis in the thymus and increased inflammation in the heart and lung.