Mild and efficient palladium/BrettPhos-catalyzed methoxylation and deuteriomethoxylation of activated aryl bromides

Abstract

A simple and efficient Pd/BrettPhos-catalyzed C–O cross-coupling reaction of activated aryl bromides with methanol and methanol-d4 has been disclosed. Bromo-chalcones were also found to have coupled effectively with methanol and methanol-d4. With increasing alkyl chain length of the primary alkyl alcohols, the catalyst system becomes inactive. The catalyst system facilitates the C–O coupling reaction even under mild reaction conditions.