Abstract
Understanding the endothelial cell migration on micropatternedpolymers, as well as the cellorientation is a critical issue in tissue engineering, since it is thepreliminary step towards cell polarization and that possibly leads to the blood vessel formation. In this paper, we derive a simple agent-based model to describe the migration and the orientation of endothelial cells seeded on bioactive micropatterned polymers. The aim of the modeling is to provide a simple model that corroborates quantitatively the experiments, without considering the complex phenomena inherent to cell migration. Our model is obtained thanks to a classical mechanics approach based on experimental observations. Even though its simplicity, it provides numerical results that are quantitatively in accordance with the experimental data, and thus our approach can be seen as a preliminary way towards a simple modeling of cell migration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Discrete and Continuous Dynamical Systems - Series B
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
