Abstract
BackgroundThe Drosophila CNS midline cells are an excellent model system to study neuronal and glial development because of their diversity of cell types and the relative ease in identifying and studying the function of midline-expressed genes. In situ hybridization experiments generated a large dataset of midline gene expression patterns. To help synthesize these data and make them available to the scientific community, we developed a web-accessible database.DescriptionMidExDB (Drosophila CNS Midline Gene Expression Database) is comprised of images and data from our in situ hybridization experiments that examined midline gene expression. Multiple search tools are available to allow each type of data to be viewed and compared. Descriptions of each midline cell type and their development are included as background information.ConclusionMidExDB integrates large-scale gene expression data with the ability to identify individual cell types providing the foundation for detailed genetic, molecular, and biochemical studies of CNS midline cell neuronal and glial development and function. This information has general relevance for the study of nervous system development in other organisms, and also provides insight into transcriptional regulation.
Highlights
The Drosophila CNS midline cells are an excellent model system to study neuronal and glial development because of their diversity of cell types and the relative ease in identifying and studying the function of midline-expressed genes
The basic data searches return information from alkaline phosphatase (AP) data and confocal data, while the confocal query tool returns information based on expression in specific cell types
The basic data searches (Category, Gene, and Quick) are located on the MidExDB Home page, and the confocal query tool can be accessed on the navigation menu (Figure 2A)
Summary
The goal of MidExDB is to disseminate information about the Drosophila CNS midline cells. MidExDB is able to search and integrate a large-scale midline gene expression dataset. The database provides a useful foundation for studying CNS midline development and function, the underlying regulatory circuitry. Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical researc h in our lifetime.". Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright.
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