Middle-late pregnancy outcomes of patients with cervical length no more than 3 cm before pregnancy in-vitro fertilization and embryo transfer treatment

Abstract

Objective To evaluate the middle-late pregnancy outcomes of patients who were clinical pregnancy with cervical length no more than 3 cm before pregnancy in-vitro fertilization and embryo transfer (IVF-ET) treatment. Methods A retrospective analysis was performed on infertile women with embryo transfer from May 2009 to December 2014 in our center. There were 86 patients who were clinical pregnancy with cervical length no more than 3 cm on transfer day, among whom 8 cases were miscarriage, and the rest 78 patients with ongoing pregnancy as study groups. A total of 225 patients whose clinical pregnancy with cervical length more than 3 cm as control groups, among whom 32 cases were miscarriage and the rest 193 patients with ongoing pregnancy. By comparing different cervical length of single pregnancy group (single pregnancy group 1 and group 3) and the twin pregnancy group (twins pregnancy group 2 and group 4) late miscarriage rate, premature birth rate respectively, the risks of adverse middle-late pregnancy outcomes in patients with cervical length no more than 3 cm were analyzed. Results The proportion of patients with cervical length no more than 3 cm before pregnancy in single pregnancy group 1 was significantly higher than the cervical length more than 3 cm in single pregnancy group 3(18.7% vs. 7.3%)(P 0.05). Meanwhile, there was no significant difference in the proportion of late miscarriage between the patients with cervical length more than 3 cm before pregnancy in twins pregnancy group 4 and patients with cervical length no more than 3 cm before pregnancy in twins pregnancy group 2(33.3% vs. 19.5%), as well as the premature birth(20.0% vs. 19.6%)(P>0.05). Conclusion The adverse middle-late pregnancy outcome might be more likely happen in patients with cervical length no more than 3 cm before pregnancy. Key words: In-vitro fertilization and embryo transfer; Cervical length; Late miscarriage; Premature birth