Abstract

Objective To investigate the effects of endometriosis (EMS) on the outcome of pregnancy and the factors associated with pregnancy outcome after in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) treatment in infertile patients. Methods Totally 55 oocyte retrieval cycles of 46 cases of EMS associated with infertility patients were selected as EMS group. And 156 oocyte retrieval cycles of 126 cases of non EMS patients during the same period were selected as control group. The clinical data were analyzed between the two groups retrospectively, and a further analysis of the factors associated with pregnancy outcome in the two groups was performed. Results The levels of CA-125 and the canceling rate of the cycle in EMS group was significantly higher than the control (P<0.05); basic antrol follicle count (AFC), number of mature follicles on the hCG injection day, retrieved oocytes, MII oocytes, pronuclear (2PN), normal cleavage, high-quality embryo and high-quality embryo rate in EMS group were significantly lower than those in the control (P<0.05). The correlation regression coefficient between number of mature follicles on hCG injection day and infertility outcomes in patients with EMS was less than 0. Conclusion Ovarian reserve function in infertility patients with EMS is decreased, and the quality of eggs and embryos are decreased, which is more likely to cancel cycles. But the egg maturation rate, normal fertilization rate and clinical outcome in infertile patients with EMS have no significant difference when compared with infertility patients without EMS. The number of mature follicles on hCG injection day is the protective factor of pregnancy in EMS patients. Key words: Endometriosis (EMS); In vitro fertilization and embryo transfer (IVF-ET); Clinical pregnancy rate; Live birth rate

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