Microwave-assisted synthesis of pyrano[2,3-c]-pyrazole derivatives and their anti-microbial, anti-malarial, anti-tubercular, and anti-cancer activities

Abstract

We have described solvent-free preparation of new pyrano[2,3-c]-pyrazole-5-carbonitriles (1-10) from the reaction of 1,3-diketo ester, aryl hydrazine, aromatic aldehyde, and malononitrile catalyzed by Zinc triflate (which was recycled and reused up to five times) under microwave irradiation (MWI) at 80–120 °C. An augmented yield with shorter reaction times is the added advantage of the present work. All synthesized molecules were screened for anti-malarial, anti-microbial, anti-tuberculosis, and anti-cancer activities. Most of the tested compounds exhibited prominent anti-bacterial and anti-malarial activity, and some analogs showed anti-cancer activity.